Dr. Majid Ali, MD

[Karl J. West]

The work of Dr. Ali is some of the most impressive I can find with regard to Cellular Ecology in this day and age. His ORPEC hypothesis is strikingly similar to that of my fathers theory of Interstitial Lymphatic Occlusion and as I develop the Theory of Ecological Origins it will certainly be "hand in glove". I am just now cracking open his 3rd Volume of The Principles & Practices of Integrative Medicine entitled Dysoxygenosis and Oxystatic Therapies. Already I can see that it will be a Bible of Cellular Ecology to me. There are numerous concepts that I have long known to be true being delineated therein.

Here is one I am so impressed to see:

The Leaky Cell Membrane State

"In 1987, in Leaky Cell Membrane Dysfunction, I presented the biochemical and clinical consequences of an increased cell membrane permeability state caused by relentless oxidative stress. The cell membrane gets shot full of holes, so to speak, and the cell hemorrages out and what is on the outside of the cell floods the cell's innards. For Example, intracellular levels of calcium in health are far below those of the extracellular compartments and a leaky cell membrane permits pathologic calcium influx. Excess of intracellular calcium then triggers a host of pathogenic molecular pathways, including induction of cell death by apoptosis. Concurrently, excess magnesium leaves the cell and functional magnesium deficiency impairs the function of many enzyme systems for which the mineral serves as a cofactor. From those considerations, I drew comparison between the ever-increasing indication of calcium channel blockers in pharmacological medicine and ever-sharpening focus of nutritionist-physicians on magnesium supplementation. Of course, the consequences of a leaky cell membrane state are not merely confined to the changes in intracellular calcium and magnesium levels."

Harry Hershey wrote a book called The Free Radical Story in 1986, in which the likelihood of stress involved with active transport or cellular respiration was obvious to me when I finally read it (much later but long ago).